He faces charges from encounters involving two women, including Lucia Evans.
The actress was one of the first women to go public with her story last fall in the New Yorker exposé, alleging that Weinstein forced her to perform oral sex on him at the Weinstein Company offices.
According to the Associated Press, the case also includes another victim, who has not spoken out publicly.
It is the first criminal case to be brought against Weinstein since the deluge of accusations of sexual misconduct surfaced last October.
To date, more than 75 women have accused the Hollywood producer of sexual misconduct. Authorities in California and London are still investigating assault allegations.
Weinstein has denied all allegations of non-consensual sex.
Below, watch video footage of Weinstein entering a Manhattan police precinct earlier this morning.
The disgraced producer was later seen exiting the precinct in handcuffs and is expected to appear in court later this morning.
Harvey Weinstein was just walked out of the police station in handcuffs https://t.co/xvUOsBkWRY— Meg Wagner (@megwagner) May 25, 2018
We're in the courtroom waiting for Weinstein. For so long he had his own private system— fancy lawyers who paid to silence women, private investigators and spies. Now he answers to the same system as the rest of us. pic.twitter.com/ajxYCwhATw— jodikantor (@jodikantor) May 25, 2018